The cees dekker Diaries
The cees dekker Diaries
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Working with solitary-molecule optical and AFM imaging and force-spectroscopy procedures, we search for to unravel the mechanistic facets of the construction and dynamics of chromosomes. Our research passions contain:
It absolutely was only in the nineties while, when nanotechnology experienced Sophisticated to some amount where by one molecules can be manipulated, that the primary experimental products began to seem.
[Laughs] ‘It had been unquestionably a great risk! At the time, I was well aware that it could go Mistaken Which I could turn into a lot less profitable, but I just overlooked that. Curiosity has often been my strongest driving power. And fortuitously all of it worked out.’
2007, very first serious-time detection of strand exchange in homologous recombination by RecA; discovery of a very low persistence duration of ends of microtubules; and solved the system of biosensing with carbon nanotubes
2015, discovery that condensin is actually a highly adaptable protein construction; and first detection of DNA knots applying nanopores
The coiled-coil with the human Rad50 DNA fix protein consists of precise segments of improved flexibility
Considering that 2000 he moved to single-molecule biophysics and nanobiology, with research from DNA supercoiling experiments of nucleosomes and DNA repair service proteins to DNA translocation by way of nanopores. Not too long ago his study has centered on learning cell division with micro organism on chip, even though his greatest desire is from the path of realizing artificial cells.
2000, discovery that nanotubes can carry incredible big recent densities; resolved the controversial concern of Digital transportation via DNA molecules by measurements of insulating habits at The one molecule amount; and demonstration of the AFM method for solitary-molecule manipulation of nanotubes
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But carbon nanotubes have remained a investigation subject of substantial interest to many. Indeed, the outlook on using carbon nanotubes to make simple products, in regions for example radio-frequency electronics, digital electronics and versatile electronics, continues to be vivid.
An integrated microfluidic platform for quantifying drug permeation across biomimetic vesicle membranes
‘That considerations the artificial cell, as Section of the Dutch BaSyC initiative. Craig Venter appeared leading-down in All those days and recognized about 5 hundred genes that are minimally necessary for just a functioning cell. We wish to glimpse bottom-up: how do we go from the few molecules to a whole Organic procedure?
Electrical transportation in monolayers of phthalocyanine molecular wires and AFM imaging of just one wire bridging two electrodes
Solid-point out nanopores have proven to be a remarkably versatile probe for single-molecule analysis of DNA. I'll explain several of our new results – exclusively DNA knots – and also our attempts ceesdekker.net to increase the capabilities of solid-point out nanopores even further more, from the course of solitary-protein detection, graphene nanopores, plasmonic nanopores, and DNA origami nanopores.